The placebo effect works -- even when the patient knows it's a placebo -- demonstrating that it is a 'ritual of medicine' and not an attempt to fool patients, according to the results of a small randomized clinical trial.
In the trial of 80 irritable bowel syndrome (IBS) patients, those who took an open-label placebo showed clinically meaningful -- and statistically significantly -- higher global improvement scores and reduced symptom severity compared with those who got the same physician attention but didn't pop a placebo pill, Ted J. Kaptchuk, OMD (Doctor of Oriental Medicine), of the Beth Israel Deaconess Medical Center and Harvard, and colleagues found.
In the trial of 80 irritable bowel syndrome (IBS) patients, those who took an open-label placebo showed clinically meaningful -- and statistically significantly -- higher global improvement scores and reduced symptom severity compared with those who got the same physician attention but didn't pop a placebo pill, Ted J. Kaptchuk, OMD (Doctor of Oriental Medicine), of the Beth Israel Deaconess Medical Center and Harvard, and colleagues found.
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