In the 2009 Glucosamine/chondrotin Arthritis Intervention Trial or GAIT, found that people with knee osteoarthritis who took supplements with glucosamine and chondrotin sulfate showed no difference in the loss of cartilage in their knees than those taking a placebo. In the study, published in Arthritis & Rheumatism, researchers tracked 572 people with moderate or severe OA in one or both knees.
Those who took part in this study took either glucosamine, chondrotin, glucosamine plus chondrotin, the anti-inflammatory drug celecoxib or Celebrex, or placebo for two years. The x-rays of the affected knee joint were examined before and after treatment and the width of the space between the bones in the knee were measured.
A narrower joint space means that the cartilage of the bone ends has worn away, which is a clear sign of OA. The study found no significant difference in joint space narrowing among the groups, but researchers did note that the results were complicated because the joint space narrowing among people taking placebo was much less than expected.
But, overall, the results were inconclusive, like an earlier GAIT result about the supplements being used as a pain reliever.
Sited from January/Feburary 2009 Arthritis Management
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